Born in Terni, he started to compose music very early when he was just seven years old, even before the beginning of his musical studies. After graduating in Piano at G. Briccialdi in Terni, he continued his studies in various Conservatories such as S. Cecilia in Rome, L. Cherubini in Florence, F. Morlacchi in Perugia and obtained Degrees in Composition, Conducting, Choral music and Choir Conducting. Up to date holds a teaching position at F. Morlacchi Conservatory. 

His career as conductor took off with his performance in Spoleto of  Un Ballo in maschera of Verdi, obtaining great public success and positive reviews from the critics.

Later Carlo Palleschi was invited to conduct orchestras from all different parts of the world including: Tchaikowsky Symphony Orchestra of radio Moscow, Tchec National Philharmonic, Slovak Philarmonie of Bratislava, Bern Festival Orch, Vancouver I. Orchestra, Budapest Philharmonic, Seoul Philharmonic, Aachen Philharmonisches Orch., Orchestra Sinfonica Siciliana, Staats Philharmonie Reinland Pfalz, Edmonton Symphony, Toronto Chamber Orch., Orch. Sinf. De Cordoba, Losanna Symphony, KBS Symphony, Korean Symphony, State Symphony Orchestra of Mexico, Hermitage Symphony of St. Pietroburgo, Kitchener Waterloo Symphony of Canada, Kiev Philharmonic, Orch. Sinf. De Extremadura, Orchestra Internazionale d’Italia, Archov Philharmonic, National Philharmonic of Brasil, Orchestra Philharmonica Marchigiana, Philharmonisches Orchestre Heidelberg etc.

He has been guest conductor with many opera companies. He has conducted in Arena of Verona, Comunale of Firenze, Sferisterio of Macerata, Carlo Felice of Genova, Bellini of Catania, Festival Pucciniano of Torre del lago, Festival of Spoleto, Politeama of Greco di Lecce, Teatro Verdi of Trieste, Tokyo Bunkakaikan Theater, Ontario Opera of Hamilton, New Israeli Opera House of Tel Aviv, Arena of Avenches, Gran Castle in Bellinzona, Pala Congressi Theatre of Genev in Switzerland, Metropolitan Opera House in Seoul and National Theater of Korea. He also has conducted the First National representation of Falstaff and I Puritani in Korea.

Carlo Palleschi has conducted in some prestigious Concert Halls of the world as the Carnegie Hall of New York, the Philharmonie and the Shauspielhaus in Berlin, the Seoul Art Center Concert Hall, theBig Hall of Tchaikovsky Conservatory in Moscow, the Philarmonie in München, the Alte Oper and the Jharehundert Halle of Frankfurt, the Salle Erasme of Strasburg,the Theater of Bellas Artes in Mexico City etc.
In 1995 he was appointed as Principal Guest Conductor of Korean symphony orchestra, Seoul.

In the year 2000 he was appointed as Artistic and Music Director of the Symphonic Orchestra of Tito Schipa Foundation of Lecce (Italy).

In 2001 he became Artistic Director of the Festival Lirica in Piazza of the City of Massa Marittima. In 2004 he was appointed Artistic Director of Tradition Theatre Politeama Greco in Lecce.

He has conducted eminent opera singers such as L. Pavarotti, K.Ricciarelli, L. Nucci, G. Dimitrova, G. Casolla, R. Kabaiwanska, L. Bartolini, R. Bruson, J. Cura, M.Devia, R. Raimondi, C. Guelfi, S. Bonfadelli, A. Mastromarino, N. Fantini, C. Colombara, G. Scalchi, W. Matteuzzi, P. Cappuccilli, L. Alva, N. Martinucci, D. Voight, B. Ford etc..

He has also worked with soloists such as I. Oistrakh, P. B. Skoda, A. DeLarrocha, J.Achucharro, R. Filippini, A. Ciccolini, H. Schellenberger, R. Cappello, M. Damerini, G. Carmignola, E.Dindo, M. Zanini, S.Pedroni, A. Adorjan, M. Ursuleasa, C. Rossi, R. Rizzi, O. Kern, A. Nei man etc.

In 2001, Mr. Palleschi conducted 
Rita of Donizetti and Le villi of Puccini. The perfomances were recorded live for the label Kikko Music of Milan.

In 2002, he conducted Il Barbiere di Siviglia which was recorded live. He also conducted Il Corsaro of Verdi which was recorded live by Raisat for Worldvision.

His repertories include all symphonic repertories and more than 40 operas: Aida, La Traviata, Rigoletto, Il Trovatore, Il Corsaro, Macbeth, Requiem, Otello, I due Foscari, Un Ballo in Maschera, Simon Boccanegra, Nabucco, Falstaff, Tosca, Turandot, Suor Angelica, Manon Lescaut, Gianni Schichi, Tabarro, La Boheme, Le Villi, Madama Butterfly, Adriana Lecouvreur, Carmen, Sansone et Dalila, Andrea Chenièr, L’Elisir d’amore Il Barbiere di Siviglia, Tancredi, Il viaggio a Reims, L'Italiana in Algeri, Le nozze di Figaro, Don Giovanni, Cosi fan tutte, Cavalleria Rusticana, Puritani, Sonnambula, Lucia di Lammermore, Werther, Fedora, Rita etc.

For the first anniversary of the World Cup 2002 - Korea and Japan he conducted Turandot of Puccini at the World Cup Stadium in Seoul in co-production with Teatro Comunale of Florence, State's Opera of Peizing and Korea Arena Opera Festival with the direction of Thang Yi-mou.
He has been invited as a member of the jury of XIV Competition for young conductors of European Union 2007 Franco Capuana which took place in Spoleto.

2010L’heure espagnole in Messina.

2011: Gianni Schicchi Suor Angelica a Messina.

2012: Traviata – Spoleto.

2013: Tosca – Spoleto.